Tissue-specific differentiation of CD8 resident memory T cells

K Yang; A Kallies

Journal article

Tissue-specific differentiation of CD8 resident memory T cells

K Yang, A Kallies

Trends in Immunology | Published : 2021

DOI: 10.1016/j.it.2021.08.002

Abstract

CD8+ tissue-resident memory T (TRM) cells play crucial roles in defense against infections and cancer and have been implicated in autoimmune diseases such as psoriasis. In mice and humans, they exist in all nonlymphoid organs and share key characteristics across all tissues, including downregulation of tissue egress and lymph node homing pathways. However, recent studies demonstrate considerable heterogeneity across TRM cells lodged in different tissues – linked to the activity of tissue-specific molecules, including chemokines, cytokines, and transcription factors. Current work indicates that transforming growth factor (TGF)-β plays a major role in generating TRM heterogeneity at phenotypic..

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University of Melbourne Researchers

Axel Kallies Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was funded by the National Health and Medical Research Council (NHMRC, Fellowship 1139607 and Project Grant 1147409 to A.K.) . We would also like to thank Laura Mackay and two reviewers for their constructive comments.